{"id":47983,"date":"2024-12-13T15:26:28","date_gmt":"2024-12-13T07:26:28","guid":{"rendered":"https:\/\/www.abesmoke.com\/?p=47983"},"modified":"2024-12-13T15:26:59","modified_gmt":"2024-12-13T07:26:59","slug":"d08f099459","status":"publish","type":"post","link":"https:\/\/www.abesmoke.com\/en\/a\/47983","title":{"rendered":"Introduction to Disintegrants in Orally Disintegrating Tablets"},"content":{"rendered":"
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Orally disintegrating tablets (ODTs) are a novel oral dosage form designed to disintegrate rapidly in the mouth without the need for chewing. Upon contact with saliva, these tablets dissolve quickly, allowing for easy swallowing and subsequent passage into the stomach.With advantages such as ease of administration, rapid onset of action, and minimal gastrointestinal side effects, it has gained immense popularity in the market.<\/span><\/span><\/p>\n

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Currently, both domestically and internationally, the direct compression method is commonly employed to produce this dosage form, which imposes stringent quality requirements on pharmaceutical excipients, such as excellent compressibility, flowability, and rapid disintegration properties.<\/span><\/p>\n

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The excipients in ODTs can be primarily categorized into three components: disintegrants, fillers, and flavoring agents. Among these, disintegrants play a crucial role in the ODT formulation, while fillers and flavoring agents are used to adjust the tablet weight and enhance palatability, respectively. Consequently, this article will focus on the various types of disintegrants.<\/span><\/p>\n

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1.Microcrystalline Cellulose<\/span><\/strong><\/p>\n

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\u5fae\u6676\u7ea4\u7ef4\u7d20\uff08MCC\uff09\u53ef\u538b\u578b\u597d\uff0c\u9047\u6c34\u4f1a\u7834\u574f\u5206\u5b50\u94fe\u4e4b\u95f4\u7684\u6c22\u952e\uff0c\u7247\u5242\u5f97\u4ee5\u8fc5\u901f\u5d29\u89e3\uff0c\u4f46\u4e0d\u4f1a\u5438\u6c34\u6eb6\u80c0\uff0c\u901a\u5e38\u4e0e\u5176\u5b83\u6eb6\u80c0\u6027\u80fd\u5f3a\u7684\u8f85\u6599\u914d\u5408\u4f7f\u7528\uff0c\u4ee5\u589e\u5f3a\u5d29\u89e3\u6027\u3002\u5982\u5fae\u6676\u7ea4\u7ef4\u7d20\u4e0e\u4ea4\u8054\u805a\u4e59\u70ef\u5421\u54af\u70f7\u916e\u8054\u5408\u5e94\u7528\u52a0\u5feb\u53e3\u8154\u5d29\u89e3\u7247\u7684\u5d29\u89e3\u8fc7\u7a0b\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.Crosslinked Carboxymethyl Cellulose Sodium<\/span><\/strong><\/p>\n

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\u4ea4\u8054\u7fa7\u7532\u7ea4\u7ef4\u7d20\u94a0\u7684\u5d29\u89e3\u673a\u5236\u662f\u5f3a\u6eb6\u80c0\u6027\u548c\u5b54\u9699\u7387\uff0c\u4ea4\u8054\u7fa7\u7532\u7ea4\u7ef4\u7d20\u94a0\u4fdd\u7559\u7ea4\u7ef4\u7d20\u7684\u03b2\u6298\u53e0\u7ed3\u6784\uff0c\u7528\u91cf\u5c0f\u65f6\uff0c\u4e5f\u80fd\u53d1\u751f\u6bdb\u7ec6\u7ba1\u4f5c\u7528\u5bfc\u81f4\u7684\u5d29\u89e3\u3002\u5f3a\u5438\u6c34\u6eb6\u80c0\u6027\u4e5f\u4fdd\u8bc1\u5176\u9ad8\u6548\u5d29\u89e3\u80fd\u529b\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5185\u52a02%\u7684\u4ea4\u8054\u7fa7\u7532\u7ea4\u7ef4\u7d20\u94a0\u4f5c\u4e3a\u5d29\u89e3\u5242\u53ef\u5927\u5927\u7f29\u77ed\u5d29\u89e3\u65f6\u95f4\uff0c\u540c\u65f6\u7247\u5242\u7684\u786c\u5ea6\u548c\u8106\u788e\u5ea6\u4e5f\u4e0d\u4f1a\u53d7\u5230\u5f71\u54cd\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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3.Crosslinked Polyvinylpyrrolidone<\/span><\/strong><\/p>\n

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\u4ea4\u8054\u805a\u7ef4\u916e\u80fd\u5728\u6c34\u4e2d\u80fd\u8fc5\u901f\u6eb6\u80c0\uff0c\u5d29\u89e3\u6027\u80fd\u4f18\u8d8a\uff0c\u5e38\u7528\u4f5c\u9ad8\u6548\u5d29\u89e3\u5242\u3002\u6709\u7814\u7a76\u62a5\u9053\uff0c\u5f53\u52a0\u4eba5-8%\u7684\u4ea4\u8054\u805a\u4e59\u70ef\u5421\u54af\u70f7\u916e\u65f6\uff0c\u6da6\u6e7f\u65f6\u95f4\u7f29\u77ed\uff0c\u800c\u52a0\u4eba\u91cf\u57288-15%\u95f4\uff0c\u53cd\u800c\u4f1a\u5ef6\u957f\u5176\u6da6\u6e7f\u65f6\u95f4\u3002\u5176\u539f\u56e0\u53ef\u80fd\u662f\u9ad8\u6d53\u5ea6\u7684\u4ea4\u8054\u805a\u4e59\u70ef\u5421\u54af\u70f7\u916e\u589e\u52a0\u6eb6\u6db2\u9ecf\u5ea6\uff0c\u6291\u5236\u6c34\u5206\u5b50\u7684\u6e17\u900f\uff0c\u4ece\u800c\u5ef6\u7f13\u4e86\u7247\u5242\u7684\u89e3\u4f53\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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4.Carboxymethyl Starch Sodium<\/span><\/strong><\/p>\n

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\u7fa7\u7532\u6dc0\u7c89\u94a0\u5177\u6709\u826f\u597d\u7684\u81a8\u80c0\u6027\u548c\u5438\u6c34\u6027\uff0c\u81a8\u80c0\u540e\u7684\u4f53\u79ef\u589e\u5927\u81f3\u539f\u6765\u7684200-300\u500d\uff0c\u81a8\u80c0\u4f5c\u7528\u5747\u5300\u800c\u5145\u5206\u5e76\u4e14\u4e0d\u4f1a\u5f62\u6210\u80f6\u4f53\u6eb6\u6db2\u3002\u5176\u53ef\u538b\u6027\u597d\uff0c\u591a\u7528\u4e8e\u76f4\u63a5\u538b\u7247\uff0c\u80fd\u591f\u589e\u52a0\u7247\u5242\u7684\u786c\u5ea6\uff0c\u6539\u5584\u7247\u5242\u7684\u6210\u5f62\u6027\u4e14\u4e0d\u5f71\u54cd\u5176\u5d29\u89e3\u6027\u80fd\uff0c\u4e00\u822c\u7528\u91cf\u57284-8%\u4e4b\u95f4\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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5.Co-processed Excipients<\/span><\/strong><\/p>\n

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Co-processed excipients have gradually evolved into disintegrants, including the co-processed combination of microcrystalline cellulose and colloidal silicon dioxide, mannitol, fructose, cross-linked polyvinylpyrrolidone, as well as starch-lactose and mannitol-lactose complexes, which serve as solutions for excipients in oral disintegrating tablets.<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6765\u6e90\uff1a\u5c71\u6cb3\u836f\u8f85<\/span><\/section>\n<\/section>\n
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\u539f\u6587\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff08\u96fe\u5316\u79d1\u6280\u5c55\uff09\uff1aIntroduction to Disintegrants in Orally Disintegrating Tablets<\/a><\/p>\n<\/section>\n<\/div>","protected":false},"excerpt":{"rendered":"

\u00a0 \u53e3\u8154\u5d29\u89e3\u7247\uff08Orally disintegrating tablet\uff09\u7b80\u79f0ODT\uff0c\u662f\u4e00\u79cd\u65b0\u578b\u53e3\u670d\u5242\u578b\uff0c\u6307\u653e\u4e8e\u53e3\u4e2d\uff0c\u4e0d\u9700\u8981\u5480\u56bc\uff0c\u9047\u553e\u6db2\u5373\u53ef\u8fc5\u901f\u5d29\u89e3\uff0c\u541e\u54bd\u540e\u5373\u53ef\u5165\u80c3\u7684\u5242\u578b\uff0c\u5177\u6709\u670d\u7528\u65b9\u4fbf\u3001\u8d77\u6548\u5feb\u548c\u5bf9\u80a0\u80c3\u526f\u4f5c\u7528\u5c0f\u7b49\u4f18\u70b9\uff0c\u6df1\u53d7\u5e02\u573a …<\/p>","protected":false},"author":2,"featured_media":47984,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-47983","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"jetpack_publicize_connections":[],"_links":{"self":[{"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/posts\/47983","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/comments?post=47983"}],"version-history":[{"count":0,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/posts\/47983\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/media\/47984"}],"wp:attachment":[{"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/media?parent=47983"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/categories?post=47983"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/tags?post=47983"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}