{"id":47966,"date":"2024-12-13T11:26:15","date_gmt":"2024-12-13T03:26:15","guid":{"rendered":"https:\/\/www.abesmoke.com\/?p=47966"},"modified":"2024-12-13T11:27:31","modified_gmt":"2024-12-13T03:27:31","slug":"db3684a634","status":"publish","type":"post","link":"https:\/\/www.abesmoke.com\/en\/a\/47966","title":{"rendered":"Process Analysis of Oral Thin Film Formulation"},"content":{"rendered":"
\n
\n
\n
\n
\n

\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

Formulation of Oral Thin Film<\/span><\/strong>
<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n

A typical formulation composition for Oral Thin Film is as follows: Active pharmaceutical ingredient: 30%; Water-soluble film-forming polymer: 40-50%; Plasticizer: 0-20%; Excipients, colorants, flavoring agents, etc.: 0-40%.
<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\n
\n
\n

\u539f\u6599\u836f<\/span><\/strong>\uff1a\u539f\u6599\u836f\u7684\u7c92\u5f84\u6216\u7c92\u5ea6\u5206\u5e03\u53ca\u6676\u578b\u7684\u8d28\u91cf\u5c5e\u6027\u5c06\u5bf9\u5236\u5242\u6eb6\u51fa\u901f\u7387\u9020\u6210\u5f71\u54cd\uff0c\u6b64\u5916\u5728\u53e3\u6eb6\u819c\u5236\u5907\u8fc7\u7a0b\u4e2d\uff0c\u7531\u4e8e\u539f\u6599\u836f\u6eb6\u89e3\u6027\u8d28\u53ef\u80fd\u4f1a\u53d1\u751f\u91cd\u7ed3\u6676\u73b0\u8c61\uff0c\u5236\u5907\u8fc7\u7a0b\u4e2d\u539f\u6599\u836f\u6676\u578b\u68c0\u6d4b\u4e5f\u975e\u5e38\u91cd\u8981\u3002
<\/span><\/p>\n

\u00a0<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u6c34\u6eb6\u6027\u6210\u819c\u805a\u5408\u7269<\/span><\/strong>\uff1a\u6c34\u6eb6\u6027\u6210\u819c\u805a\u5408\u7269\u7684\u6027\u8d28\u5c06\u5f71\u54cd\u5236\u5242\u7684\u7c98\u9644\u6027\u3001\u5d29\u89e3\u65f6\u9650\u3001\u8f7d\u836f\u91cf\u53ca\u673a\u68b0\u6027\u80fd\u7b49\u8d28\u91cf\u7279\u6027\uff0c\u5176\u6750\u6599\u6027\u8d28\u7684\u7406\u89e3\uff0c\u6709\u52a9\u4e8e\u5206\u6790\u53e3\u6eb6\u819c\u5242\u578b\u91ca\u653e\u7279\u6027\uff0c\u5efa\u7acb\u66f4\u5177\u9884\u6d4b\u6027\u836f\u4ee3\u52a8\u529b\u5b66\u6a21\u578b\u3002<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u76ee\u524d\u5728\u53e3\u6eb6\u819c\u5904\u65b9\u4e2d\u5e7f\u6cdb\u4f7f\u7528\u7684\u6c34\u6eb6\u6027\u6210\u819c\u805a\u5408\u7269\u5305\u62ec\uff1a\u7ea4\u7ef4\u7d20\u7c7b\u3001\u6dc0\u7c89\u7c7b\u3001\u534a\u5408\u6210\u3001\u5408\u6210\u7684\u6210\u819c\u805a\u5408\u7269\u7b49\uff0c\u5176\u7279\u6027\u5982\u4e0b\u8868\u6240\u793a\uff1a
<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u6c34\u6eb6\u6027\u6210\u819c\u805a\u5408\u7269\u7279\u6027<\/span><\/p>\n

\"Process<\/p>\n

\n

\u4e0d\u540c\u7c7b\u578b\u6210\u819c\u6750\u6599\u6216\u4e0d\u540c\u6bd4\u4f8b\u6210\u819c\u6750\u6599\u5236\u5907\u7684\u53e3\u6eb6\u819c\u5177\u6709\u4e0d\u540c\u7684\u91ca\u653e\u901f\u7387\uff0c\u5229\u7528\u836f\u4ee3\u52a8\u529b\u5b66\u6a21\u578b\u5bf9\u4e0d\u540c\u91ca\u653e\u901f\u7387\u7684\u53e3\u6eb6\u819c\u8fdb\u884c\u836f\u4ee3\u52a8\u529b\u5b66\u53c2\u6570\u8fdb\u884c\u5206\u6790\uff0c\u53ef\u66f4\u6e05\u6670\u7406\u89e3\u6210\u819c\u6750\u6599\u5bf9\u4f53\u5185\u5916\u91ca\u653e\u5f71\u54cd\u7684\u76f8\u5173\u6027\u3002

\u589e\u5851\u5242<\/strong>\uff1a\u589e\u5851\u5242\u53ef\u4e0e\u6c34\u6eb6\u6027\u6210\u819c\u805a\u5408\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u6709\u5229\u4e8e\u819c\u5242\u7684\u5206\u88c5\u548c\u5207\u5272\u3002\u5e38\u7528\u7684\u589e\u5851\u5242\u6709\u7518\u6cb9\u3001\u805a\u4e59\u4e8c\u9187\uff08PEG400\uff09\u3001\u5c71\u68a8\u9187\u3001\u4e19\u4e8c\u9187\u7b49\u3002\u6709\u6587\u732e\u62a5\u9053\u589e\u5851\u5242\u53ef\u80fd\u5f71\u54cd\u539f\u6599\u836f\u6eb6\u89e3\u5ea6\u548c\u836f\u7269\u7684\u5438\u6536\uff0c\u56e0\u6b64\u5728\u5904\u65b9\u7814\u7a76\u4e5f\u9700\u5173\u6ce8\u589e\u5851\u5242\u79cd\u7c7b\u53ca\u7528\u91cf\u7684\u7814\u7a76\u3002

\u586b\u5145\u5242\u3001\u8272\u7d20\u3001\u77eb\u5473\u5242\u7b49\u5176\u4ed6\u8f85\u6599<\/strong>\uff1a\u53e3\u6eb6\u819c\u53e3\u611f\u662f\u5f71\u54cd\u4e34\u5e8a\u53d7\u8bd5\u8005\u8131\u843d\u7684\u5173\u952e\u56e0\u7d20\uff0c\u4e5f\u662f\u53e3\u6eb6\u819c\u7684\u5173\u952e\u8d28\u91cf\u5c5e\u6027\u4e4b\u4e00\uff0c\u751c\u5473\u5242\u65f6\u5e38\u88ab\u7528\u4f5c\u819c\u5242\u4e2d\u8d77\u77eb\u5473\u4f5c\u7528\uff0c\u7ecf\u5e38\u88ab\u4f7f\u7528\u7684\u751c\u5473\u5242\u5305\u62ec\u8517\u7cd6\u3001\u8461\u8404\u7cd6\u3001\u7cd6\u7cbe\u94a0\u3001\u963f\u65af\u5df4\u751c\u3001\u4e09\u6c2f\u8517\u7cd6\u7b49\uff0c\u5176\u4e2d\u4e09\u6c2f\u8517\u7cd6\u7531\u4e8e\u5176\u751c\u5ea6\u9ad8\u3001\u5b89\u5168\u6027\u9ad8\u3001\u80fd\u91cf\u4f4e\uff0c\u5728\u5404\u56fd\u7684\u4e0a\u5e02\u54c1\u79cd\u90fd\u5305\u542b\uff1b\u90e8\u5206\u54c1\u79cd\u4e5f\u4f1a\u91c7\u7528\u79bb\u5b50\u4ea4\u6362\u6811\u8102\u7b49\u63a9\u5473\u6280\u672f\uff0c\u63a9\u76d6\u836f\u7269\u82e6\u5473\u3002<\/span><\/p>\n

\u00a0<\/span><\/p>\n

Due to the inherent characteristics of the active pharmaceutical ingredient, such as poor solubility and stability, it is advisable to include surfactants in the formulation or to prepare a nanosuspension or cyclodextrin complex to enhance solubility. Additionally, incorporating stabilizers may improve the formulation's stability. Modifying the solubility of the active ingredient with excipients can significantly impact the drug's bioavailability; therefore, if the clinical comparator does not utilize relevant excipients, careful selection is warranted.<\/span><\/p>\n

\u00a0<\/span><\/p>\n

source:\u65b0\u9886\u5148\u533b\u836f\u79d1\u6280<\/span><\/span><\/p>\n

\u539f\u6587\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff08\u96fe\u5316\u79d1\u6280\u5c55\uff09\uff1a<\/span>Process Analysis of Oral Thin Film Formulation<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/div>","protected":false},"excerpt":{"rendered":"

\u4e00\u3001\u53e3\u6eb6\u819c\u5904\u65b9 \u53e3\u6eb6\u819c\u5178\u578b\u5904\u65b9\u7ec4\u6210\u5982\u4e0b:\u539f\u6599\u836f\uff1a30%\uff1b\u6c34\u6eb6\u6027\u6210\u819c\u805a\u5408\u7269\uff1a40-50%\uff1b\u589e\u5851\u5242\uff1a0-20%\uff1b\u586b\u5145\u5242\u3001\u8272\u7d20\u3001\u77eb\u5473\u5242\u7b49\u7b49\uff1a0-40%\u3002 \u00a0 \u539f\u6599\u836f\uff1a\u539f\u6599\u836f\u7684\u7c92\u5f84\u6216\u7c92\u5ea6\u5206\u5e03\u53ca\u6676\u578b\u7684\u8d28\u91cf\u5c5e\u6027\u5c06\u5bf9\u5236\u5242\u6eb6\u51fa\u901f\u7387 …<\/p>","protected":false},"author":2,"featured_media":47967,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-47966","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"jetpack_publicize_connections":[],"_links":{"self":[{"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/posts\/47966","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/comments?post=47966"}],"version-history":[{"count":0,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/posts\/47966\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/media\/47967"}],"wp:attachment":[{"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/media?parent=47966"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/categories?post=47966"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/tags?post=47966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}