{"id":47810,"date":"2024-12-09T09:20:45","date_gmt":"2024-12-09T01:20:45","guid":{"rendered":"https:\/\/www.abesmoke.com\/?p=47810"},"modified":"2024-12-09T09:21:24","modified_gmt":"2024-12-09T01:21:24","slug":"ea6b2de591","status":"publish","type":"post","link":"https:\/\/www.abesmoke.com\/en\/a\/47810","title":{"rendered":"Development and Evaluation Focus of Oral Thin Film (OTF) New Drugs."},"content":{"rendered":"
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\u300a\u836f\u5b66\u7814\u7a76\u300b\u00b72024 Vol.43\uff0cNo.3<\/strong><\/em><\/p>\n

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In the development of new drugs,OTF offer distinct advantages for specific diseases and populations. They address many inconveniences faced by patients who have difficulties with traditional oral formulations, such as tablets, pills, and capsules, particularly those who may resist medication, such as individuals with mental health conditions. Consequently, they have garnered increasing attention. This article explores the market status of orally disintegrating film new drug products, recommends development project initiatives, discusses formulation process development, and emphasizes quality control, aiming to provide insights for the development and evaluation of such products.<\/span><\/p>\n

It is important to note that not all medications are suitable for development as OTF. When companies embark on the development of new OTF products, they should conduct a comprehensive evaluation of the proposed formulations, carefully considering the suitability of the dosage form and whether the clinical advantages are substantial. Additionally, they must ensure compliance with the relevant requirements for the classification of innovative or improved new drugs to mitigate registration risks.<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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2006\u5e74\uff0c\u65e5\u672c\u00a0<\/strong><\/span>\u4e0a\u5e02\u4e86\u7b2c\u4e00\u4e2a\u53e3\u6eb6\u819c\u5904\u65b9\u836f\u4f0f\u683c\u5217\u6ce2\u7cd6\u53e3\u6eb6\u819c\u30022010\u5e74\uff0c\u7f8e\u56fd\u548c\u6b27\u6d32\u00a0<\/strong><\/span>\u5206\u522b\u4e0a\u5e02\u7b2c\u4e00\u4e2a\u53e3\u6eb6\u819c\u5904\u65b9\u836f\u6602\u4e39\u53f8\u743c\u53e3\u6eb6\u819c\uff08Rapidfilm\u548cSetofilm\uff09\u30022020\u5e74\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u00a0<\/strong><\/span>\u6279\u51c6\u4e86\u7b2c\u4e00\u4e2a\u53e3\u6eb6\u819c\u5316\u5b66\u836f\u54c1\u5965\u6c2e\u5e73\u53e3\u6eb6\u819c\u4e0a\u5e02\u3002\u76ee\u524d\uff0c\u5168\u7403\u5df2\u6709\u591a\u4e2a\u53e3\u6eb6\u819c\u4ea7\u54c1\u4e0a\u5e02\uff0c\u67e5\u8be2\u7f8e\u56fd[6]\u3001\u6b27\u6d32[7]\u3001\u65e5\u672c[8]\u836f\u54c1\u76d1\u7ba1\u673a\u6784\u7f51\u7ad9\uff0c\u90e8\u5206\u54c1\u79cd\u4fe1\u606f\u89c1\u88681\u3002<\/p>\n

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\u5178\u578b\u7684\u53e3\u6eb6\u819c\u5904\u65b9\u901a\u5e38\u5305\u62ec<\/strong><\/span>\uff1a\u836f\u7269\u6d3b\u6027\u6210\u5206\uff085%~30%W\/W\uff09\u3001\u6210\u819c\u6750\u6599\uff0840%~50%W\/W\uff09\u3001\u589e\u5851\u5242\uff080~20%W\/W\uff09\uff0c\u5fc5\u8981\u65f6\u6dfb\u52a0\u8868\u9762\u6d3b\u6027\u5242\uff08\u9002\u91cf\uff09\u3001\u751c\u5473\u5242\uff083%~6%W\/W\uff09\u3001\u553e\u6db2\u523a\u6fc0\u5242\u3001\u586b\u5145\u5242\u3001\u9999\u7cbe\u548c\u8272\u7d20\u7b49[10]\u3002<\/span><\/p>\n

\u56fd\u5185\u6279\u51c6\u4e0a\u5e02\u7684\u4ea7\u54c1\u5904\u65b9\u4e2d<\/strong><\/span>\uff0c\u4e00\u822c\u4e3b\u8981\u5305\u62ec\u6210\u819c\u6750\u6599\uff08\u5982\u7f9f\u4e19\u7532\u7ea4\u7ef4\u7d20\uff09\u3001\u589e\u5851\u5242\uff08\u5982\u7518\u6cb9\u3001\u805a\u4e59\u4e8c\u9187400\uff09\u3001\u77eb\u5473\u5242\uff08\u5982\u4e09\u6c2f\u8517\u7cd6\u3001\u9999\u7cbe\uff09\u3001\u7740\u8272\u5242\u7b49\u3002<\/p>\n

\u8c03\u7814\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08Food and Drug Administration\uff0cFDA\uff09\u6279\u51c6\u4e0a\u5e02\u7684\u53e3\u6eb6\u819c\u5904\u65b9\u5982\u88683\u6240\u793a\u3002\u5176\u4e2d\u7f9f\u4e19\u7532\u7ea4\u7ef4\u7d20\u3001\u7f9f\u4e19\u57fa\u7ea4\u7ef4\u7d20\u4e3a\u5e38\u7528\u7684\u6210\u819c\u6750\u6599\uff0c\u7518\u6cb9\u3001\u7518\u6cb9\u5355\u6cb9\u9178\u916f\u4e3a\u5e38\u7528\u7684\u589e\u5851\u5242\uff0c\u4e09\u6c2f\u8517\u7cd6\u3001\u9999\u7cbe\u4e3a\u5e38\u7528\u7684\u77eb\u5473\u5242\u3002<\/p>\n

\"Development<\/strong><\/span><\/p>\n

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\u6210\u819c\u6750\u6599\u662f\u00a0<\/strong><\/span>\u836f\u7269\u6d3b\u6027\u6210\u5206\u7684\u8f7d\u4f53\uff0c\u662f\u53e3\u6eb6\u819c\u5904\u65b9\u4e2d\u6700\u91cd\u8981\u7684\u6210\u5206\u4e4b\u4e00\uff0c\u4e00\u822c\u4e3a\u4eb2\u6c34\u805a\u5408\u7269\uff08\u5982\u7f9f\u4e19\u7532\u57fa\u7ea4\u7ef4\u7d20\u7b49\uff09\u3002\u6210\u819c\u6750\u6599\u805a\u5408\u7269\u7684\u79cd\u7c7b\u548c\u7528\u91cf\u5f71\u54cd\u53e3\u6eb6\u819c\u7684\u62c9\u4f38\u5f3a\u5ea6\uff0c\u805a\u5408\u7269\u7684\u5206\u5b50\u91cf\u5f71\u54cd\u53e3\u6eb6\u819c\u7684\u6eb6\u5316\u65f6\u9650\u3002\u589e\u5851\u5242\u53ef\u63d0\u9ad8\u53e3\u6eb6\u819c\u7684\u673a\u68b0\u6027\u80fd\uff0c\u5305\u62ec\u62c9\u4f38\u5f3a\u5ea6\u548c\u5ef6\u4f38\u7387\uff0c\u5e38\u89c1\u7684\u589e\u5851\u5242\u6709\u7518\u6cb9\u3001\u805a\u4e59\u4e8c\u9187\uff08PEG400\uff09\u7b49\u3002<\/p>\n

\u589e\u5851\u5242\u7684\u9009\u62e9\u00a0<\/strong><\/span>\u53d6\u51b3\u4e8e\u5176\u4e0e\u805a\u5408\u7269\u7684\u76f8\u5bb9\u6027\u548c\u6eb6\u5242\u6027\u8d28\u7b49\u3002\u6709\u7814\u7a76\u8868\u660e\uff0c\u5904\u65b9\u4e2d\u589e\u5851\u5242\u4e0e\u6210\u819c\u6750\u6599\u7684\u6bd4\u4f8b\u5bf9\u53e3\u6eb6\u819c\u7684\u673a\u68b0\u6027\u80fd\uff08\u65ad\u88c2\u4f38\u957f\u7387\u3001\u6768\u6c0f\u6a21\u91cf\u3001\u6298\u53e0\u8010\u4e45\u6027\uff09\u3001\u539a\u5ea6\u3001\u6eb6\u51fa\u5ea6\u7b49\u5173\u952e\u8d28\u91cf\u5c5e\u6027\u4ea7\u751f\u663e\u8457\u5f71\u54cd[15]\u3002\u8868\u9762\u6d3b\u6027\u5242\u4e00\u822c\u7528\u4e8e\u589e\u5f3a\u53e3\u6eb6\u819c\u7684\u6eb6\u89e3\u5ea6\u548c\u6da6\u6e7f\u6027\uff0c\u4f7f\u836f\u7269\u6d3b\u6027\u6210\u5206\u66f4\u5feb\u91ca\u653e\u3002<\/p>\n

\u751c\u5473\u5242\u00a0<\/strong><\/span>\u7528\u4e8e\u63a9\u76d6\u836f\u7269\u6d3b\u6027\u6210\u5206\u7684\u96be\u95fb\u6c14\u5473\u548c\u82e6\u5473\u3002\u553e\u6db2\u523a\u6fc0\u5242\u53ef\u523a\u6fc0\u553e\u6db2\u817a\u4ea7\u751f\u553e\u6db2\uff0c\u5e2e\u52a9\u53e3\u6eb6\u819c\u5feb\u901f\u5206\u89e3\u3002\u5904\u65b9\u5f00\u53d1\u8fc7\u7a0b\u53ca\u4e34\u5e8a\u8bd5\u9a8c\u671f\u95f4\uff0c\u5e94\u5173\u6ce8\u53e3\u611f\u6307\u6807\u7684\u6536\u96c6\u4e0e\u8bc4\u4ef7\uff08\u5c24\u5176\u6d3b\u6027\u6210\u5206\u5473\u9053\u96be\u4ee5\u63a9\u76d6\u7684\u54c1\u79cd\uff09\uff0c\u5e76\u6839\u636e\u9700\u8981\u4f18\u5316\u5904\u65b9\u3002<\/p>\n

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\u5728\u5904\u65b9\u5f00\u53d1\u65f6\uff0c\u8fd8\u9700\u5173\u6ce8\u00a0\u539f\u6599\u836f\u7c92\u5ea6\u53ca\u6676\u578b\u7684\u7814\u7a76<\/strong><\/span>\uff0c\u5c24\u5176\u662f\u96be\u6eb6\u6027\u836f\u7269\u3002\u5f53\u836f\u7269\u6d3b\u6027\u6210\u5206\u5728\u5236\u5242\u4e2d\u95f4\u4f53\u836f\u6db2\u4e2d\u5448\u6df7\u60ac\u72b6\u6001\uff0c\u5173\u6ce8\u539f\u6599\u836f\u7c92\u5ea6\u5206\u5e03\u7684\u63a7\u5236\uff0c\u4ee5\u4fdd\u8bc1\u914d\u6db2\u836f\u6db2\u53ca\u6210\u54c1\u542b\u91cf\u5747\u4e00\u6027\uff0c\u4ee5\u53ca\u6210\u54c1\u819c\u8868\u9762\u5149\u6ed1\u5e73\u6574\u3002\u5efa\u8bae\u7ed3\u5408\u7c92\u5ea6\u5bf9\u5236\u5242\u7279\u6027\uff08\u5982\u6027\u72b6\u5916\u89c2\u3001\u542b\u91cf\u5747\u5300\u6027\u3001\u6eb6\u51fa\u5ea6\uff09\u3001\u751f\u4ea7\u5de5\u827a\uff08\u5982\u5206\u6563\u5747\u5300\u6027\u3001\u5b58\u653e\u7a33\u5b9a\u6027\uff09\u7b49\u7684\u5f71\u54cd\uff0c\u5236\u5b9a\u7c92\u5f84\u63a7\u5236\u7b56\u7565\u3002\u9664\u5e94\u5bf9\u53e3\u6eb6\u819c\u7684\u539f\u8f85\u6599\u8fdb\u884c\u5408\u7406\u63a7\u5236\u5916\uff0c\u8fd8\u5efa\u8bae\u5173\u6ce8\u79bb\u578b\u819c\u7684\u6750\u8d28\u548c\u578b\u53f7\u7684\u9009\u62e9\u3001\u8d28\u63a7\uff0c\u8bc4\u4f30\u5176\u5bf9\u4ea7\u54c1\u4ea7\u751f\u7684\u5f71\u54cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Part.<\/strong>02<\/strong><\/section>\n<\/section>\n<\/section>\n
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\u53e3\u6eb6\u819c\u7684\u8d28\u91cf\u7814\u7a76\u53ca\u8bc4\u4ef7\u5173\u6ce8\u70b9<\/strong><\/section>\n<\/section>\n
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\u819c\u5242\u7684\u5236\u5907\u5de5\u827a\u00a0<\/strong><\/span>\u4e3b\u8981\u5305\u62ec\u6d82\u819c\u6cd5\u3001\u70ed\u7194\u6324\u51fa\u6cd5\u3001\u534a\u56fa\u4f53\u6eb6\u5242\u6d47\u94f8\u6cd5\u3001\u56fa\u4f53\u5206\u6563\u6324\u538b\u6cd5\u548c\u6eda\u5706\u6cd5\u7b49[18]\u3002\u5176\u4e2d\u6d82\u819c\u6cd5\u662f\u76ee\u524d\u5546\u4e1a\u5316\u751f\u4ea7\u53e3\u6eb6\u819c\u8f83\u4e3a\u666e\u904d\u7684\u65b9\u6cd5\u3002<\/span><\/p>\n

\u6d82\u819c\u6cd5\u00a0<\/strong><\/span>\u9996\u5148\u5c06\u6210\u819c\u6750\u6599\u6eb6\u89e3\u4e8e\u6c34\u6216\u6709\u673a\u6eb6\u5242\u6216\u4e24\u8005\u7684\u6df7\u5408\u6eb6\u5242\u4e2d\uff0c\u5f62\u6210\u5177\u6709\u4e00\u5b9a\u9ecf\u5ea6\u7684\u900f\u660e\u72b6\u6eb6\u6db2\u3002\u5f53\u836f\u7269\u6d3b\u6027\u6210\u5206\u4e3a\u6c34\u6eb6\u6027\u65f6\uff0c\u5e94\u4e0e\u6210\u819c\u6750\u6599\u5236\u6210\u5177\u6709\u4e00\u5b9a\u9ecf\u5ea6\u7684\u6eb6\u6db2\uff1b\u5f53\u836f\u7269\u6d3b\u6027\u6210\u5206\u4e3a\u6c34\u4e0d\u6eb6\u6216\u96be\u6eb6\u65f6\uff0c\u5e94\u5c06\u5176\u7c89\u788e\u5e76\u4e0e\u6210\u819c\u6750\u6599\u7b49\u6df7\u5408\u5747\u5300\u3002\u518d\u5c06\u836f\u7269\u548c\u5176\u4ed6\u8f85\u6599\u6eb6\u89e3\u6216\u5206\u6563\u5230\u4e0a\u8ff0\u6eb6\u6db2\u4e2d\uff0c\u771f\u7a7a\u8131\u6c14\uff0c\u5012\u5165\u6d82\u819c\u673a\u4e2d\u6d82\u819c\uff0c\u771f\u7a7a\u5e72\u71e5\u9664\u53bb\u6c34\u5206\uff0c\u8131\u6a21\u540e\u88c1\u526a\u6210\u6240\u9700\u89c4\u683c\uff0c\u5373\u5f97\u3002\u6d82\u819c\u6cd5\u662f\u5236\u5907\u53e3\u6eb6\u819c\u5e38\u7528\u7684\u65b9\u6cd5\uff0c\u8be5\u65b9\u6cd5\u5236\u5907\u5de5\u827a\u7b80\u5355\uff0c\u52a0\u5de5\u6210\u672c\u4f4e\uff0c\u6613\u4e8e\u4f7f\u7528[19]\u3002<\/p>\n

\u5de5\u827a\u5f00\u53d1\u65f6\u5e94\u5bf9\u53c2\u7167ICHQ8[20]\u5bf9\u751f\u4ea7\u5de5\u827a\u548c\u5de5\u827a\u53c2\u6570\u8fdb\u884c\u5168\u9762\u7684\u7b5b\u9009\u7814\u7a76\uff0c\u4ee5\u52a0\u5f3a\u5bf9\u4ea7\u54c1\u6027\u80fd\u548c\u5de5\u827a\u7684\u7406\u89e3\uff0c\u5efa\u7acb\u5de5\u827a\u53c2\u6570\u4e0e\u5236\u5242\u5173\u952e\u8d28\u91cf\u5c5e\u6027\uff08\u5982\u8584\u819c\u539a\u5ea6\u3001\u6eb6\u5316\u65f6\u9650\u3001\u6eb6\u51fa\u5ea6\u3001\u6c34\u5206\u3001\u5438\u6e7f\u6027\u3001\u542b\u91cf\u548c\u542b\u91cf\u5747\u5300\u5ea6\u3001\u673a\u68b0\u6027\u80fd\u7b49\uff09\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u5e76\u91c7\u53d6\u6709\u6548\u7684\u8fc7\u7a0b\u63a7\u5236\u63aa\u65bd\u3002\u5728\u91c7\u7528\u6d82\u819c\u6cd5\u751f\u4ea7\u53e3\u6eb6\u819c\u65f6\uff0c\u5f71\u54cd\u836f\u54c1\u5173\u952e\u8d28\u91cf\u5c5e\u6027\u7684\u9ad8\u98ce\u9669\u5de5\u827a\u6b65\u9aa4\u901a\u5e38\u4e3a\u914d\u6db2\u3001\u8131\u6ce1\u3001\u6d82\u5e03\u548c\u5e72\u71e5\u3002\u914d\u6db2\u5de5\u5e8f\u5efa\u8bae\u5173\u6ce8\u5bf9\u914d\u6599\u6e29\u5ea6\u3001\u52a0\u6599\u987a\u5e8f\u3001\u6df7\u5408\u53c2\u6570\u7684\u7814\u7a76\u548c\u63a7\u5236\u3002\u8131\u6ce1\u5de5\u5e8f\uff0c\u5efa\u8bae\u8003\u8651\u80f6\u6db2\u4e2d\u7684\u6c14\u6ce1\u6b8b\u7559\u5bf9\u6d82\u5e03\u5de5\u827a\u548c\u4ea7\u54c1\u8d28\u91cf\u7684\u5f71\u54cd\u3002\u6d82\u5e03\u548c\u5e72\u71e5\u5de5\u5e8f\uff0c\u5efa\u8bae\u5173\u6ce8\u98ce\u91cf\u3001\u5e72\u71e5\u6e29\u5ea6\u7b49\u53c2\u6570\u7684\u7814\u7a76\u548c\u63a7\u5236\uff0c\u5c24\u5176\u5f53\u836f\u7269\u6d3b\u6027\u6210\u5206\u5728\u80f6\u6db2\u4e2d\u5448\u6df7\u60ac\u72b6\u6001\u65f6\uff0c\u5efa\u8bae\u91cd\u70b9\u5173\u6ce8\u5728\u5de5\u827a\u8fc7\u7a0b\u4e2d\u4ea7\u54c1\u7684\u5747\u4e00\u6027\uff0c\u5305\u62ec\u80f6\u6db2\u653e\u7f6e\u8fc7\u7a0b\u4e2d\u7684\u5747\u4e00\u6027\u3001\u6d82\u5e03\u8fc7\u7a0b\u4e2d\u80f6\u6db2\u7684\u5747\u4e00\u6027\u7b49\u3002\u6b64\u5916\u5173\u6ce8\u751f\u4ea7\u8fc7\u7a0b\u4e2d\u662f\u5426\u4f1a\u51fa\u73b0\u79bb\u578b\u819c\u6362\u5377\u6216\u6d82\u5e03\u8fc7\u7a0b\u4e2d\u8bbe\u5907\u505c\u673a\u7b49\u60c5\u5f62\uff0c\u82e5\u5b58\u5728\uff0c\u5219\u5efa\u8bae\u8fdb\u884c\u98ce\u9669\u8bc4\u4f30\uff0c\u5e76\u63d0\u51fa\u76f8\u5e94\u7684\u5904\u7406\u65b9\u5f0f\u53ca\u5176\u5408\u7406\u6027\u4f9d\u636e\u3002<\/p>\n

\u6d82\u819c\u6cd5\u5236\u5907\u53e3\u6eb6\u819c\u751f\u4ea7\u8fc7\u7a0b\u4e2d\u7684\u5236\u5242\u4e2d\u95f4\u4ea7\u54c1\u901a\u5e38\u5305\u62ec\u80f6\u6db2\u3001\u6d82\u5e03\u5e72\u71e5\u540e\u836f\u819c\u3001\u88c1\u5207\u540e\u836f\u819c\u3001\u5185\u5305\u540e\u836f\u819c\u7b49\u3002\u5e94\u6839\u636e\u4e0d\u540c\u5de5\u827a\u7684\u98ce\u9669\u70b9\uff0c\u9488\u5bf9\u6027\u5730\u5f00\u5c55\u8fc7\u7a0b\u63a7\u5236\u3001\u4e2d\u95f4\u4f53\u63a7\u5236\u3002\u5176\u4e2d\u80f6\u6db2\u4e2d\u95f4\u4f53\u5173\u6ce8\u6837\u54c1\u7684\u6027\u72b6\u3001\u6c14\u6ce1\u3001\u9ecf\u5ea6\u3001\u542b\u91cf\u3001\u5fae\u751f\u7269\u9650\u5ea6\u7b49\uff1b\u6d82\u5e03\u5e72\u71e5\u540e\u836f\u819c\u5173\u6ce8\u6837\u54c1\u7684\u6027\u72b6\u3001\u7247\u91cd\u3001\u542b\u91cf\u53ca\u542b\u91cf\u5747\u5300\u6027\u3001\u6c34\u5206\u3001\u673a\u68b0\u6027\u80fd\u7b49\uff1b\u88c1\u5207\u540e\u548c\u5185\u5305\u540e\u836f\u819c\u5173\u6ce8\u6837\u54c1\u7684\u5c3a\u5bf8\u3001\u7247\u91cd\u5dee\u5f02\u3001\u5bc6\u5c01\u6027\u3001\u673a\u68b0\u6027\u80fd\u7b49\u3002<\/p>\n

\u5728\u5de5\u827a\u5f00\u53d1\u8fc7\u7a0b\u4e2d\uff0c\u4f01\u4e1a\u5e94\u8ba4\u771f\u5206\u6790\u751f\u4ea7\u89c4\u6a21\u653e\u5927\u5bf9\u4ea7\u54c1\u8d28\u91cf\u53ef\u80fd\u4ea7\u751f\u7684\u5f71\u54cd\uff0c\u7ed3\u5408\u62df\u5b9a\u7684\u5546\u4e1a\u751f\u4ea7\u89c4\u6a21\uff0c\u5408\u7406\u9009\u62e9\u4e34\u5e8a\u8bd5\u9a8c\u7528\u6837\u54c1\u6279\u91cf\u3002\u5efa\u8bae\u5546\u4e1a\u5316\u6837\u54c1\u5904\u65b9\u5de5\u827a\u3001\u6279\u91cf\u4e0e\u5173\u952e\u4e34\u5e8a\u8bd5\u9a8c\u6837\u54c1\u4fdd\u6301\u4e00\u81f4\uff0c\u4e0d\u4f4e\u4e8e10\u4e07\u7247\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Part.<\/strong>03<\/strong><\/section>\n<\/section>\n<\/section>\n
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\u751f\u4ea7\u5de5\u827a\u53ca\u8fc7\u7a0b\u63a7\u5236<\/strong><\/section>\n<\/section>\n
<\/section>\n
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\u300a\u4e2d\u56fd\u836f\u5178\u300b2020\u5e74\u7248<\/strong><\/span>\uff08\u56db\u90e8\uff090125\u819c\u5242\u901a\u5219\u4e2d\u89c4\u5b9a[3]\uff0c\u819c\u5242\u5916\u89c2\u5e94\u5b8c\u6574\u5149\u6d01\u3001\u539a\u5ea6\u4e00\u81f4\u3001\u8272\u6cfd\u5747\u5300\u3001\u65e0\u660e\u663e\u6c14\u6ce1\u3002\u591a\u5242\u91cf\u7684\u819c\u5242\uff0c\u5206\u683c\u538b\u75d5\u5e94\u5747\u5300\u6e05\u6670\uff0c\u5e76\u80fd\u6309\u538b\u75d5\u6495\u5f00\u3002\u9664\u53e6\u6709\u89c4\u5b9a\u5916\uff0c\u819c\u5242\u5e94\u8fdb\u884c\u91cd\u91cf\u5dee\u5f02\uff08\u51e1\u8fdb\u884c\u542b\u91cf\u5747\u5300\u5ea6\u68c0\u67e5\u7684\u819c\u5242\uff0c\u4e00\u822c\u4e0d\u518d\u8fdb\u884c\u91cd\u91cf\u5dee\u5f02\u68c0\u67e5\uff09\u3001\u5fae\u751f\u7269\u9650\u5ea6\uff08\u5fae\u751f\u7269\u8ba1\u6570\u6cd5\u548c\u63a7\u5236\u83cc\u68c0\u67e5\u6cd5\u53ca\u975e\u65e0\u83cc\u836f\u54c1\u5fae\u751f\u7269\u9650\u5ea6\u6807\u51c6\u68c0\u67e5\uff0c\u5e94\u7b26\u5408\u89c4\u5b9a\uff09\u7684\u68c0\u67e5\u3002\u56fd\u5bb6\u836f\u5178\u59d4\u5458\u4f1a\u53d1\u5e03\u5173\u4e8e\u5f81\u6c42\u300a\u4e2d\u56fd\u836f\u5178\u300b\u4e38\u5242\u548c\u819c\u5242\u901a\u5219\u4fee\u8ba2\u8349\u6848\u516c\u5f00\u5f81\u6c42\u610f\u89c1[4]\u4e2d\u5bf9\u819c\u5242\u5728\u751f\u4ea7\u4e0e\u8d2e\u85cf\u671f\u95f4\u7684\u8981\u6c42\u8fdb\u884c\u4fee\u8ba2\uff0c\u589e\u52a0\u4e86\u53e3\u611f\u3001\u53e3\u8154\u9ecf\u819c\u523a\u6fc0\u6027\u3001\u6c34\u5206\u3001\u673a\u68b0\u6027\u80fd\u3001\u5fae\u751f\u7269\u9650\u5ea6\u3001\u6eb6\u51fa\u5ea6\u3001\u542b\u91cf\u5747\u5300\u5ea6\u53ca\u6b8b\u7559\u6eb6\u5242\u65b9\u9762\u7684\u8981\u6c42\u3002\u5728\u53e3\u6eb6\u819c\u5b9a\u4e49\u4e2d\u8fd8\u6307\u51fa\uff0c\u53e3\u6eb6\u819c\u5e94\u8fdb\u884c\u6eb6\u5316\u65f6\u9650\u68c0\u67e5\uff0c\u5bf9\u4e8e\u96be\u6eb6\u6027\u539f\u6599\u836f\u7269\u5236\u6210\u7684\u53e3\u6eb6\u819c\uff0c\u8fd8\u5e94\u8fdb\u884c\u6eb6\u51fa\u5ea6\u68c0\u67e5\u3002\u9664\u5e38\u89c4\u8d28\u91cf\u63a7\u5236\u9879\u76ee\u5916\uff0c\u6839\u636e\u819c\u5242\u7684\u7279\u70b9\u53ca\u5173\u952e\u8d28\u91cf\u5c5e\u6027\uff0c\u5efa\u8bae\u91cd\u70b9\u5173\u6ce8\u8bc4\u4ef7\u53e3\u6eb6\u819c\u7684\u6c34\u5206\u3001\u53e3\u611f\u3001\u6eb6\u5316\u65f6\u9650\u3001\u6eb6\u51fa\u5ea6\u4ee5\u53ca\u673a\u68b0\u6027\u80fd\u3002<\/p>\n

\u6c34\u5206\uff1a<\/span><\/strong>\u53e3\u6eb6\u819c\u4e2d\u5e94\u542b\u6709\u9002\u91cf\u7684\u6c34\u5206\uff0c\u4ee5\u4fdd\u969c\u53e3\u6eb6\u819c\u5177\u6709\u9002\u5b9c\u7684\u673a\u68b0\u6027\u80fd\uff0c\u4ee5\u514d\u5305\u88c5\u3001\u8fd0\u8f93\u8fc7\u7a0b\u4e2d\u53d1\u751f\u78e8\u635f\u6216\u7834\u788e\u3002<\/p>\n

\u53e3\u611f\uff1a<\/strong><\/span>\u53e3\u6eb6\u819c\u5e94\u53e3\u611f\u826f\u597d\uff0c\u4e3a\u4e86\u6ee1\u8db3\u4f9d\u4ece\u6027\u9700\u8981\uff0c\u5efa\u8bae\u5728\u4e34\u5e8a\u7814\u7a76\u8fc7\u7a0b\u4e2d\u5173\u6ce8\u7ed9\u836f\u65b9\u5f0f\uff08\u53e3\u8154\u653e\u7f6e\u4f4d\u7f6e\u3001\u6eb6\u5316\u65f6\u9650\u7b49\uff09\u3001\u9ecf\u819c\u9ecf\u9644\u6027\u548c\u523a\u6fc0\u6027\u3001\u53e3\u8154\u5c40\u90e8\u4e0d\u826f\u53cd\u5e94\u3001\u53e3\u611f\u8bc4\u4ef7\u7b49[4]\u3002<\/p>\n

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\u6eb6\u51fa\u5ea6\uff1a<\/span><\/strong>\u53e3\u6eb6\u819c\u9700\u8981\u5feb\u901f\u91ca\u653e\u836f\u7269\uff0c\u4ee5\u786e\u4fdd\u6d3b\u6027\u836f\u7269\u6210\u5206\u5728\u670d\u7528\u540e\u53ef\u88ab\u5438\u6536\u3002\u5728\u53e3\u6eb6\u819c\u5f00\u53d1\u7684\u521d\u671f\u98ce\u9669\u8bc4\u4f30\u4e2d\uff0c\u6eb6\u51fa\u5ea6\u901a\u5e38\u662f\u9ad8\u98ce\u9669\u8d28\u91cf\u5c5e\u6027\uff0c\u5e94\u91cd\u70b9\u5173\u6ce8\u3002\u5728\u5f00\u5c55\u53e3\u6eb6\u819c\u6eb6\u51fa\u5ea6\u65b9\u6cd5\u5f00\u53d1\u65f6\uff0c\u5efa\u8bae\u8003\u8651\u53e3\u6eb6\u819c\u819c\u7247\u8d28\u8f7b\u6613\u6f02\u6d6e\u7b49\u5236\u5242\u7279\u70b9\uff0c\u5173\u6ce8\u6eb6\u51fa\u88c5\u7f6e\u3001\u6eb6\u51fa\u8bd5\u9a8c\u53c2\u6570\u3001\u53d6\u6837\u65f6\u95f4\u70b9\u7b49\u9009\u62e9\u7684\u5408\u7406\u6027\uff0c\u5efa\u7acb\u5408\u9002\u7684\u3001\u5177\u6709\u4e00\u5b9a\u533a\u5206\u80fd\u529b\u7684\u6eb6\u51fa\u5ea6\u65b9\u6cd5\u3002\u8bc1\u660e\u6eb6\u51fa\u65b9\u6cd5\u533a\u5206\u80fd\u529b\u65f6\uff0c\u53ef\u5236\u5907\u5173\u952e\u7269\u6599\u5c5e\u6027\u3001\u5173\u952e\u5904\u65b9\u7ec4\u6210\u3001\u5173\u952e\u5de5\u827a\u53c2\u6570\u53d1\u751f\u53d8\u5316\uff08\u4f8b\u5982\uff0c\u53c2\u6570\u5728\u8bbe\u5b9a\u503c\u00b110%\u00b120%\u7684\u53d8\u5316\uff09\u7684\u6837\u54c1\uff0c\u63d0\u4f9b\u4e0d\u540c\u6837\u54c1\u6eb6\u51fa\u66f2\u7ebf\u5bf9\u6bd4\u6570\u636e[21]\u3002\u5bf9\u4e8e\u96be\u6eb6\u6027\u836f\u7269\u5236\u5907\u7684\u53e3\u6eb6\u819c\uff0c\u6eb6\u51fa\u65b9\u6cd5\u5efa\u8bae\u5bf9\u4e0d\u540c\u7c92\u5f84\u7684\u5904\u65b9\u5177\u6709\u4e00\u5b9a\u7684\u533a\u5206\u80fd\u529b[22]\u3002<\/p>\n

\u673a\u68b0\u6027\u80fd\uff1a<\/strong><\/span>\u53e3\u6eb6\u819c\u4ea7\u54c1\u673a\u68b0\u6027\u80fd\u7684\u7814\u7a76\u4e0d\u5bb9\u5ffd\u89c6\uff0c\u673a\u68b0\u6027\u80fd\u5728\u53e3\u6eb6\u819c\u836f\u7269\u7684\u64cd\u4f5c\u6027\u3001\u7ed9\u836f\u4fbf\u5229\u6027\u548c\u7a33\u5b9a\u6027\u65b9\u9762\u5747\u6709\u91cd\u8981\u5f71\u54cd[11]\u3002\u5efa\u8bae\u6839\u636e\u53e3\u6eb6\u819c\u7684\u4e34\u5e8a\u4f7f\u7528\u573a\u666f\u548c\u7279\u70b9\uff0c\u5173\u6ce8\u4ea7\u54c1\u5546\u4e1a\u5305\u88c5\u548c\u8fd0\u8f93\u88c5\u8f7d\u65b9\u5f0f\uff0c\u8fdb\u884c\u6a21\u62df\u88c5\u8f7d\u3001\u8fd0\u8f93\u3001\u968f\u8eab\u643a\u5e26\uff08\u53ef\u80fd\u6d89\u53ca\u8dcc\u843d\u3001\u649e\u51fb\u3001\u76b1\u8936\u7b49\u60c5\u51b5\uff09\u7814\u7a76\uff0c\u6ce8\u610f\u5bf9\u53ef\u80fd\u4ea7\u751f\u7684\u819c\u7247\u788e\u88c2\u7b49\u60c5\u51b5\u8fdb\u884c\u8003\u5bdf\u3002<\/p>\n

\u53e3\u6eb6\u819c\u7684\u673a\u68b0\u6027\u80fd\u7684\u8bc4\u4ef7\u6307\u6807\u53ef\u53c2\u8003\u4f46\u4e0d\u9650\u4e8e[10]\uff1a\u2460\u6297\u62c9\u5f3a\u5ea6\uff08tensile strength\uff09\uff1a\u662f\u8584\u819c\u6837\u54c1\u5728\u67d0\u4e00\u70b9\u65ad\u88c2\u65f6\u65bd\u52a0\u7684\u6700\u5927\u5e94\u529b\uff0c\u8ba1\u7b97\u65b9\u5f0f\u4e3a\u7528\u65ad\u88c2\u65f6\u65bd\u52a0\u7684\u529b\u9664\u4ee5\u8584\u819c\u7684\u6a2a\u622a\u9762\u79ef\uff1b\u2461\u4f38\u957f\u7387\uff08percent elongation\uff09\uff1a\u5f53\u65bd\u52a0\u62c9\u529b\u65f6\uff0c\u8584\u819c\u6837\u54c1\u4f1a\u62c9\u4f38\u4ea7\u751f\u5f62\u53d8\u3002\u4f38\u957f\u7387\u4e3a\u8584\u819c\u4f38\u957f\u91cf\u5360\u539f\u6765\u957f\u5ea6\u7684\u767e\u5206\u7387\u3002\u8584\u819c\u4f38\u957f\u7387\u4e00\u822c\u968f\u589e\u5851\u5242\u542b\u91cf\u7684\u589e\u52a0\u800c\u589e\u52a0\uff1b\u2462\u6297\u6495\u88c2\u6027\uff08tear resistance\uff09\uff1a\u6495\u88c2\u8584\u819c\u6240\u9700\u7684\u6700\u5927\u529b\uff0c\u8bb0\u5f55\u4e3a\u6297\u6495\u88c2\u503c\uff08\u5355\u4f4d\u4e3a\u725b\u987f\u6216\u78c5\uff09\uff1b\u2463\u6768\u6c0f\u6a21\u91cf\uff08young\u2032s modulus\uff09\uff1a\u6768\u6c0f\u6a21\u91cf\u6216\u5f39\u6027\u6a21\u91cf\u662f\u8861\u91cf\u8584\u819c\u521a\u5ea6\u7684\u53c2\u6570\u3002\u8868\u793a\u4e3a\u5f39\u6027\u53d8\u5f62\u533a\u57df\u7684\u5e94\u529b\u4e0e\u5e94\u53d8\u4e4b\u6bd4\uff1b\u2464\u8010\u6298\u5ea6\uff08folding endur\u2043ance\uff09\uff1a\u8010\u6298\u5ea6\u662f\u901a\u8fc7\u5c06\u8584\u819c\u5728\u540c\u4e00\u4f4d\u7f6e\u53cd\u590d\u6298\u53e0\u76f4\u81f3\u8584\u819c\u7834\u88c2\u6765\u786e\u5b9a\u7684\uff0c\u8584\u819c\u6298\u53e0\u4e0d\u65ad\u88c2\u7684\u6b21\u6570\u8ba1\u4e3a\u8010\u6298\u5ea6\u503c\u3002\u8010\u6298\u5ea6\u53ef\u7528\u4e8e\u6a21\u62df\u4e34\u5e8a\u5b9e\u9645\u4f7f\u7528\u3001\u8fd0\u8f93\u3001\u8d2e\u85cf\u8fc7\u7a0b\u5bf9\u8584\u819c\u6027\u80fd\u7684\u5f71\u54cd\u3002\u5efa\u8bae\u7ed3\u5408\u53e3\u6eb6\u819c\u751f\u4ea7\u5de5\u827a\u8fc7\u7a0b\u63a7\u5236\u3001\u7a33\u5b9a\u6027\u8fc7\u7a0b\u4e2d\u7684\u673a\u68b0\u6027\u80fd\u7814\u7a76\u7ed3\u679c\uff0c\u5408\u7406\u62df\u5b9a\u53ef\u63a5\u53d7\u6807\u51c6\uff0c\u5e76\u8003\u8651\u662f\u5426\u8ba2\u5165\u8d28\u91cf\u6807\u51c6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5316\u5b66\u836f\u54c1\u6ce8\u518c\u5206\u7c7b\u4e2d2\u7c7b\u4e3a\u5883\u5185\u5916\u5747\u672a\u4e0a\u5e02\u7684\u6539\u826f\u578b\u65b0\u836f\uff0c\u5177\u4f53\u662f\u6307\u5728\u5df2\u77e5\u6d3b\u6027\u6210\u5206\u7684\u57fa\u7840\u4e0a\uff0c\u5bf9\u5176\u7ed3\u6784\u3001\u5242\u578b\u3001\u5904\u65b9\u5de5\u827a\u3001\u7ed9\u836f\u9014\u5f84\u3001\u9002\u5e94\u8bc1\u7b49\u8fdb\u884c\u4f18\u5316\uff0c\u4e14\u5177\u6709\u660e\u663e\u4e34\u5e8a\u4f18\u52bf\u7684\u836f\u54c1\u3002<\/span><\/p>\n

\u53e3\u6eb6\u819c\u5177\u6709\u5242\u91cf\u51c6\u786e\u3001\u643a\u5e26\u65b9\u4fbf\u3001\u60a3\u8005\u4f9d\u4ece\u6027\u826f\u597d\u7b49\u7279\u70b9\uff0c\u5728\u90e8\u5206\u75be\u75c5\u53ca\u9002\u5e94\u8bc1\u4eba\u7fa4\u6cbb\u7597\u4e2d\uff0c\u53e3\u6eb6\u819c\u80fd\u5f88\u597d\u89e3\u51b3\u5176\u4ed6\u5242\u578b\u6240\u5e26\u6765\u7684\u4e0d\u4fbf\uff0c\u63d0\u9ad8\u60a3\u8005\u7528\u836f\u4f9d\u4ece\u6027\u3002\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u5e76\u4e0d\u662f\u6240\u6709\u836f\u7269\u90fd\u9002\u5408\u5f00\u53d1\u6210\u4e3a\u53e3\u6eb6\u819c\u3002<\/span><\/p>\n

\u4f01\u4e1a\u5728\u7acb\u9879\u5f00\u53d1\u65f6\u00a0<\/span><\/span><\/strong>\u5e94\u5168\u9762\u8bc4\u4f30\u9002\u5e94\u8bc1\u548c\u5242\u578b\u7279\u70b9\uff0c\u5145\u5206\u8c03\u7814\u4ea7\u54c1\u56fd\u5185\u5916\u4e0a\u5e02\u60c5\u51b5\uff0c\u5145\u5206\u8003\u8651\u5242\u578b\u9002\u7528\u6027\u53ca\u4e34\u5e8a\u4f18\u52bf\u662f\u5426\u5145\u5206\uff0c\u5408\u7406\u9009\u62e9\u7533\u62a5\u7b56\u7565\u548c\u8def\u5f84\u3002\u672c\u6587\u8fd8\u91cd\u70b9\u63a2\u8ba8\u4e86\u53e3\u6eb6\u819c\u4ea7\u54c1\u5f00\u53d1\u8fc7\u7a0b\u4e2d\u7684\u5173\u6ce8\u70b9\u548c\u76f8\u5173\u8bc4\u4ef7\u8003\u8651\u3002<\/span><\/p>\n

\u5728\u53e3\u6eb6\u819c\u5904\u65b9\u5de5\u827a\u5f00\u53d1\u65f6<\/span><\/strong>\uff0c\u5e94\u6839\u636e\u4ea7\u54c1\u7279\u70b9\uff0c\u5173\u6ce8\u5f71\u54cd\u836f\u54c1\u5242\u91cf\u51c6\u786e\u6027\u3001\u836f\u7269\u5feb\u901f\u91ca\u653e\u3001\u826f\u597d\u7684\u53e3\u611f\u3001\u6ee1\u8db3\u4f7f\u7528\u9700\u6c42\u7684\u673a\u68b0\u5f3a\u5ea6\u7b49\u76f8\u5173\u56e0\u7d20\u7684\u8bc4\u4f30\u548c\u7814\u7a76\u3002<\/span><\/p>\n

\u5728\u53e3\u6eb6\u819c\u8d28\u91cf\u63a7\u5236\u4e2d<\/strong><\/span>\uff0c\u6839\u636e\u5242\u578b\u7279\u70b9\u6ce8\u610f\u6c34\u5206\u3001\u53e3\u611f\u3001\u6eb6\u5316\u65f6\u9650\u3001\u6eb6\u51fa\u5ea6\u3001\u673a\u68b0\u6027\u80fd\u7684\u7814\u7a76\uff0c\u5c24\u5176\u5e94\u5173\u6ce8\u6eb6\u5316\u65f6\u9650\u65b9\u6cd5\u5408\u7406\u6027\u4ee5\u53ca\u6eb6\u51fa\u5ea6\u65b9\u6cd5\u5177\u6709\u4e00\u5b9a\u7684\u533a\u5206\u80fd\u529b\u3002<\/span><\/p>\n<\/section>\n

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\u00a0<\/span><\/section>\n
\u6765\u6e90\uff1a\u300a\u836f\u5b66\u7814\u7a76\u300b\u00b72024 Vol.43\uff0cNo.3\uff1b\u51e1\u9ed8\u8c37<\/span><\/section>\n

\u539f\u6587\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff08\u96fe\u5316\u79d1\u6280\u5c55\uff09\uff1aDevelopment and Evaluation Focus of Oral Thin Film (OTF) New Drugs.<\/a><\/p>\n<\/section>\n<\/section>\n<\/div>","protected":false},"excerpt":{"rendered":"

\u300a\u836f\u5b66\u7814\u7a76\u300b\u00b72024 Vol.43\uff0cNo.3 \u53e3\u6eb6\u819c\u7c7b\u65b0\u836f\u7684\u5f00\u53d1\u4e0e\u8bc4\u4ef7\u63a2\u8ba8   \u65b0\u836f\u7684\u5f00\u53d1\u4e2d\uff0c\u53e3\u6eb6\u819c\u7c7b\u836f\u7269\u5728\u7279\u5b9a\u75be\u75c5\u53ca\u4eba\u7fa4\u65b9\u9762\u5177\u6709\u4e00\u5b9a\u4f18\u52bf\uff0c\u53ef\u89e3\u51b3\u4f20\u7edf\u53e3\u670d\u5236\u5242\uff08\u5982\u7247\u5242\u3001\u4e38\u5242\u3001\u80f6\u56ca\u5242\u7b49\uff09\u5bf9\u4e8e\u53e3\u670d\u56f0\u96be\u7684\u60a3\u8005\u4ee5 …<\/p>","protected":false},"author":2,"featured_media":47811,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-47810","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"jetpack_publicize_connections":[],"_links":{"self":[{"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/posts\/47810","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/comments?post=47810"}],"version-history":[{"count":0,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/posts\/47810\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/media\/47811"}],"wp:attachment":[{"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/media?parent=47810"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/categories?post=47810"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.abesmoke.com\/en\/wp-json\/wp\/v2\/tags?post=47810"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}