In the field of new tobacco products, nicotine pouches are a smoke-free product, and the selection of their core excipients directly affects product quality. Microcrystalline cellulose, as a key functional excipient, plays an irreplaceable role in the formulation of nicotine pouches.
The production process of microcrystalline cellulose determines its unique physical properties. Through the hydrolysis, washing and drying process of α-cellulose or wood pulp powder, a granular product with a porous structure is finally formed.
This special structure gives the material excellent water and oil absorption properties while maintaining good fluidity and thermal stability. In terms of safety, microcrystalline cellulose is microbially inert and non-toxic, fully meeting food and drug grade application standards.
图源自 山河药辅演讲PPT
For the special application scenario of nicotine bags, the selection of microcrystalline cellulose requires comprehensive consideration of multiple technical parameters.
- Particle size distribution is the primary consideration. The medium particle size range of 200-500μm can not only ensure fluidity during the production process, but also avoid dust problems caused by fine powder.
- The bulk density needs to be controlled within a reasonable range. Too high a density will affect the appearance of the product, while too low a density will cause difficulty in filling.
- The balance of water absorption performance is particularly critical, which is to ensure sufficient water retention capacity without excessively affecting the nicotine release characteristics.
In practical applications, microcrystalline cellulose mainly plays the dual functions of filler and moisture regulator. Through optimized selection, the processing performance and user experience of the product can be significantly improved.
图源自 山河药辅演讲PPT
Studies have shown that the use of specific types of microcrystalline cellulose can effectively solve the problem of dust flying during the production process without negatively affecting the taste. This technical improvement allows the final product to provide a more comfortable user experience while maintaining a stable release of nicotine.
Different production processes also have different requirements for the performance of microcrystalline cellulose. The dry process focuses more on the initial fluidity of the raw material, while the wet process requires the material to maintain good processing performance after absorbing water. This differentiated technical requirement has promoted the continuous innovation and professional development of microcrystalline cellulose products.
From the perspective of technological development, there is still room for optimization in the application of microcrystalline cellulose in nicotine bags. By further studying the correlation between parameters such as particle size distribution, pore structure and surface characteristics and product performance, it is expected that specialized models that better meet specific needs will be developed.
At the same time, the synergistic effect with other functional excipients is also worthy of in-depth exploration, which will provide a new technical path for improving the quality of nicotine bag products.
来源：艾邦根据山河药辅演讲PPT整理
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